Incluye índice

Section I. -- Fuel metabolism. -- Metabolic fuels and dietary components. -- The fed or absorptive state. -- Fasting. -- Section II. -- Chemical and biologic foundations of biochemistry. -- Water, acids, bases, and buffers. -- Structures of the major compounds of the body. -- Amino acids in proteins. -- Structure-function relationships in proteins. -- Enzymes as catalysts. -- Regulation of enzymes. -- Relationship between cell biology and biochemistry. -- Cell signaling by chemical messengers. -- Section III. -- Gene expression and the synthesis of proteins. -- Structure of the nucleic acids. -- Synthesis of DNA. -- Transcription: synthesis of RNA. -- Translation: synthesis of proteins. -- Regulation of gene expression. -- Use of recombinant DNA techniques in medicine. -- The molecular biology of cancer. -- Section IV: Carbohydrate metabolism, fuel oxidation, and the generation of adenosine triphosphate. -- Basic concepts in the regulation of fuel metabolism by insulin, glucagon, and other hormones. -- Cellular bioenergetics: adenosine triphosphate and O2. -- Digestion, absorption, and transport of carbohydrates. -- Generation of adenosine triphosphate from glucose, fructose, and galactose: glycolysis. -- Tricarboxylic acid cycle. -- Oxidative phosphorylation and mitochondrial function. -- Oxygen toxicity and free-radical injury. -- Formation and degradation of glycogen. -- Pentose phosphate pathway and the synthesis of glycosides, lactose, glycoproteins, and glycolipids. -- Gluconeogenesis and maintenance of blood glucose levels. -- Section V. Lipid metabolism. -- Digestion and transport of dietary lipids. -- Oxidation of fatty acids and ketone bodies. -- Synthesis of fatty acids, triacylglycerols, and the major membrane lipids. -- Cholesterol absorption, synthesis, metabolism, and fate. -- Metabolism of ethanol. -- Integration of carbohydrate and lipid metabolism. -- Section VI. Nitrogen metabolism. -- Protein digestion and amino acid absorption. -- Fate of amino acid nitrogen: urea cycle. -- Synthesis and degradation of amino acids. -- Tetrahydrofolate, vitamin B12, and S-adenosylmethionine. -- Purine and pyrimidine metabolism. -- Intertissue relationships in the metabolism of amino acids. Section VII. tissue metabolism. -- Actions of hormones that regulate fuel metabolism. -- The biochemistry of erythrocytes and other blood cells. -- Blood plasma proteins, coagulation, and fibrinolysis. -- Liver metabolism. -- Metabolism of muscle at rest and during exercise. -- Metabolism of the nervous system. -- The extracellular matrix and connective tissue.

Connect biochemistry to clinical practice! Marks' Basic Medical Biochemistry links biochemistry to physiology and pathophysiology, allowing students to apply fundamental concepts to the practice of medicine - from diagnosing patients to recommending effective treatments. Intuitively organized chapters center on hypothetical patient vignettes, highlighting the material's clinical applications; helpful icons allow for smooth navigation, making complex concepts easier to grasp. Full-color illustrations make chemical structures and biochemical pathways easy to visualize. Patient vignettes connect biochemistry to human health and disease. Clinical Notes explain patient signs or symptoms, and Method Notes relate biochemistry to the laboratory tests ordered during diagnosis. Clinical Comments link biochemical dynamics to treatment options and patient outcomes. Biochemical Comments explore directions for new research. Key Concepts and Summary Disease tables highlight the take-home messages in each chapter. Questions and answers at the end of each chapter - 470 total inside the book, with 560 more online - probe students' mastery of key concepts.